Originariamente inviata da Svers0

Originariamente inviata da Life

I nuovi psicofarmaci che usciranno interverranno anche endocrinologicamente direttamente.

Originariamente inviata da Wikipedia

Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort.[13] It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate, with IC50 values of 0.05-0.10 μg/mL for all compounds, with the exception of glutamate, which is in the 0.5 μg/mL range.[14] Hyperforin also inhibits the reuptake of glycine[15] and choline (IC50=8.5μM).[16] It also modulates acetylcholine release in rat hippocampus and facilitates acetylcholine release in the striatum.[17][18] It appears to exert these effects by activating the transient receptor potential ion channel TRPC6.[19] Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake.[19] It also antagonises the NMDA receptor, AMPA receptor and GABA receptors.[20][21]

It inhibits TRPC6-degradation.[22] Its action on the TRPC6 cation channel is also believed to be responsible for its BDNF-like modulation of dendritic spine morphology in hippocampal pyramidal neurons.[23]

Nootropic effects of hyperforin have been observed in rats.[12] There is in vivo evidence that it can reduce biomarkers of Alzheimer's Disease in animal models and in vitro,[20][24] an action it seems to share with its analogue, tetrahydrohyperforin.[25][26][27] Hyperforin promotes mitochondrial function and the development of oligodendrocytes.[28]

Hyperforin also induces cytochrome P450 enzymes CYP3A4 and CYP2C9 by binding to and activating the pregnane X receptor (PXR).[29] The induction of CYP3A caused by hypericum perforatum seems to be heavily dependent on its hyperforin content.[30]

Hyperforin has been found to be a potent inhibitor of COX-1 and 5-LO with IC50 values of 300nM and 90nM respectively, approximately 3-18 times stronger than aspirin.[31]

Hyperforin is active against methicillin-resistant strains of Staphylococcus aureus (MRSA) with a minimal inhibitory concentration (MIC) value of 1.0 μg/mL (1.86μM),[32] as well as against other gram-positive bacteria.[33] Chemical analogues of hyperforin have also exhibited in vitro activity against various bacterial species.[34] Hyperforin also has the ability to kill Plasmodium falciparum in vitro .[35]

Hyperforin also has anticancer effects in vitro and in vivo, which are likely the result of both its anti-angiogenic and pro-apoptotic effects,[36] and potentially anticlastogenic effect.[37] Several chemical analogues of hyperforin have also exhibited anticancer effects in vitro and in vivo.[38][39][40] Hyperforin also inhibits SIRT1 and SIRT2 with a IC50 of 15±0.5μM and 28±0.2μM respectively.[41]

Originariamente inviata da Badblues

Lorazepam e delorazepam sono equiparabili?

Originariamente inviata da Badblues

Lorazepam e delorazepam sono equiparabili?

Originariamente inviata da Life

Mi compro l'e-liquid con la nicotina a 6mg, mi servono dopamina serotonina e adrenalina.
È addirittura inibitore delle IMAO la nicotina, antidepressivo a tutti gli effetti

Originariamente inviata da E. Scrooge

https://www.ebay.it/itm/MELISSA-Estr...sAAOSwXeJYEg~r

Qualcuno l'ha mai provato?

Originariamente inviata da Svers0

Sono alla ricerca di un DRI, un farmaco che tocchi solo la dopamina senza intaccare pure serotonina e noradrenalina.

Originariamente inviata da Svers0

Ho appena scoperto che esistono anche sostanze che non agiscono sulla ricaptazione ma proprio fanno rilasciare dopamina, sinceramente pensavo fosse un mito.